LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson’s Disease Patients with Wearing Off: A Prospective, Open-Label Study


Background: The efficacy of LSVT-BIG for advanced Parkinson’s disease (PD) patients with wearing off remains to be determined.

Objectives: Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off.

Methods: Unified Parkinson’s Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the “on” time before and after the LSVT-BIG course.

Results: LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the “off” state at 12 weeks, with no changes in the other measures.

Conclusions: The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off.